Necrosi del capezzolo post chirurgica trattata con ossigeno-ozono terapia. Caso riportato

Post-surgery necrosis of the nipple-areola complex treated with intensive oxygen-ozone therapy. A case report.

Italo Leo MD, Maria Teresa Contaldi MD, Carlos pérez Olmedo, MD Società Scientifica di Ossigeno Ozono Terapia (SIOOT), Gorle (Bergamo), Italy
Ozonoterapia Salud, pontevedra, Spain.

Abstract
The partial or total necrosis of the nipple-areola complex (NAC) is a not rare complication of nipple-sparing
mastectomy (NSM) after breast cancer surgical treatment. In order to repair the defects dressing
changes, debridement, skin grafting or implants have been proposed. On this background “biologically
active oxygen” administrated either locally or systemically as hyperbaric oxygen or oxygen-ozone therapy
appears an attractive, safe and potentially useful approach to improve the results of conventional treatments.
Indeed “biologically active oxygen” was shown to favour healing processes due to its ability to
control infections and to stimulate regenerative processes. Based on our personal experience in the
field as well as on the available scientific literature we describe herein a successful case report of NAC
necrosis that occurred in a 50-years old women three days after NSM. We treated the patient with a
combined, local and systemic, approach of oxygen-ozone therapy. The healing was completed after 16
weeks. The procedure was safe and well tolerated. Although some evident limitations the study supports
the potentially usefulness of oxygen-ozone therapy in NAC necrosis treatment.

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